Signal Transduction Education
Receptor Pharmacology Introduction

Textbook of Receptor Pharmacology, 3^rd edition

Editors: John Foremen, Torben Johansen &
Alasdair Gibb

Hardback, 303 pages, publication date: September 2010
ISBN: 978-1-4200-5254-1
Imprint: CRC Press - Taylor & Francis Group

For the past four decades, University College London (UCL) has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. Now in its third edition, the book continues to combine current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms, thus providing an integrated analysis of the mechanisms of drug action at membrane receptors.

The hallmark of this popular text is the uniting of four major approaches to the study of receptors: (1) molecular investigation of receptor structure, (2) quantitative function studies of agonists and antagonists, (3) ligand binding, and (4) signal transduction at the cell membrane. Maintaining the second edition’s focus on cell membrane receptors and the immediate signal transduction events at the membrane, this edition includes fully updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinase as well as enhancements to the quantitative treatment of drug-receptor interactions. Several chapters contain problems and worked-out solutions, giving students the ability to test their comprehension of the material. Hundreds of diagrams and figures further enhance the text.

A time-saving resource and comprehensive learning tool, the third edition of the Textbook of Receptor Pharmacology carries on the tradition of combining classical quantitative pharmacology with up-to-date coverage of structure-function relationships of receptors and their ligands. This unique approach to signalling mechanisms is still fundamental for the validation of therapeutic compounds that interfere at the membrane receptor level. The book therefore is a must for everyone involved in drug development, ranging from fundamental research, the conduct of clinical trials, to the marketing of novel medicaments. Moreover, the book may be an eye-opener for all those who work with growth factors, hormones, interleukins, cytokines and neurotransmitters in a qualitative way (cell biology) and wish to understand the significance of receptor occupation in cellular responses. Finally, for all those working in the area of systems biology, a meaningful systems-approach to signal transduction requires a thorough understanding of how ligands interact with receptors. For this, the Textbook of Receptor Pharmacology is a very good starting point.

3^rd edition

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