Summer Schools
2004 Course Information

The course has been generously supported by the following instances:

Course Content
- This course, in English, is aimed at post graduate students (masters) with some research experience and at PhD students. Established scientists who have changed research fields are also welcome. Those with an interest in disciplines such as molecular and cellular biology, neuroscience, development, oncology and immunology will find this course valuable.

- Lectures and seminars will provide the necessary information to understand and put into context, current literature dealing with ligands, their receptors and how they signal into the cell.

- There will also be a substantial, hands on bioinformatics project running throughout the week, in which you will study, in small groups, a signalling molecule that interests you. We will supply you with a computer and provide guidance. At the end of the course, each group will present the results of their explorations in a plenary session.

- The maximum number of participants is 45

Speakers

 Philippe Bastiaens, Dynamics of signaling networks, EMBL, Germany

 Braga , Vania - Cadherin and Rho GTPases, Imperial College , London , UK

 Brown, David - G proteins as transducers, University College London, UK

 Daniel Choquet, Receptor mobility, CNRS EP 2078, Bordeaux , France

 Dolphin, Annette - G protein coupled receptors , University College London, UK

 Gammeltoft, Steen - Molecular biology of tyrosine kinase receptors, Glostrup Hospital , Denmark

 Garbay, Christiane, Blocking the growth factor Grb2 pathway, INSERM U226, Paris , France

 Genot, Elisabeth, GTPase in T cell activation, INSERM U441-IECB, Bordeaux , France

 Gibb, Alasdair - Ligand-Receptor interaction + practical, University College London, UK

 Hemmings, Brian, Protein Kinase B, Friedrich Miescher Institute, Basel , Switzerland

 Caroline Hill , TGF?1 signal transduction, Cancer Research UK , London , UK

 Hivroz,Claire - T-cell activation, Institut Curie, Paris, France

 Kramer, IJsbrand - Introduction, INSERM 441- IECB, Bordeaux , France

 Martinez-Arias, Alfonso - Wnt signalling, University of Cambridge , UK

 Violaine Moreau, GTPases and cytoskeleton, INSERM U441-IECB, Bordeaux , France

 Ellen van Obbergen, focal adhesion complex signaling, CNRS UMR 6543, Nice , France

 Pouyssegur, Jacques, MAPKinase pathway, CNRS, Nice, France

 Eric Raymond, tyrosine kinase inhibitors in the clinic, Dept Medical Oncology, Paris , France

 Paolo Sassone-Corsi, transcription and signaling (CREM/CREB), IGBMC, Illkirch , France

 Giulio Superti -Furga, cytoplasmic tyrosine protein kinases, EMBL, Germany

 Stephenson, Anne - Receptor subunit assembly (GABA and NMDA), School of Pharmacy , London , UK

 Tatham, Peter - Ca 2+ signalling, University College London, UK

 Thomas, Geraint - Signalling molecule exploration practical, University College London, UK

 Matthias Wymann, PI 3-kinase, University of Fribourg , Switzerland

 Fried Zwartkruis, Regulation and function of Ras-like GTPases, University of Utrecht, The Netherlands

Course Venu
- The course takes place in an excellent teaching building (kindly provided by ISTAB) on the campus of the University of Bordeaux 1.
- Our first class staff-restaurant "La Passerelle" will provide your meals and coffee/tea breaks.
- Participants will be accommodated in basic student housing also next to the teaching venue (if you seek more comfort, nearby hotels are available but at your own costs.
- One afternoon (bay of arcachon) and two evenings (old Bordeaux and a wine chateau) will be dedicated to the exploration of Bordeaux and its region, Aquitaine (at no extra costs).

Course Language is English.

Course Presentation
The course is divided into three sections

1. core lectures to provide a broad view of the subjects
2. seminars to provide in-depth information
3. a bio-informatics project focused on signal transduction to make you computer-literate

Course lectures and seminars
In this course we treat the subjects of :

1. receptor mechanisms
• how ligands interact with receptors,
• the relationship between receptor occupancy and cellular/tissue responses
• the action of agonists and antagonists
• molecular structure of receptors
• composing multi-subunit receptors (ion-channels)
2. signal transduction
• how receptors occupation results in receptor signaling complex formation
• G-proteins, heterotrimeric and monomeric, as molecular switches in the relay of receptor signals
• pathways downstream of:
• tyrosine kinase containing receptors (ras, ERK, PKB etc), Frz/Wnt , TGF b/ TRs
• adhesion molecules (integrins/cadherins)
• signaling pathways as targets of anti-cancer therapies