The 3rd edition of “Signal Transduction”; a book for students and teachers
“Many students have a mental model for stories (narratives), but not textbook writing (expository prose)”. From: Jennifer Cromley. 2000. Learning to think, learning to learn: what the science of thinking and learning has to offer adult education. National Institute for Literacy.
The book is richly illustrated and where possible I have opted for realistic representations of macromolecular objects. These representations may be the direct product of molecular graphics programs, using structure coordinates from the Protein Data Bank, or they may be artists’ impressions of experimentally determined structures and include anatomically accurate simplifications. For pedagogical arguments I refer to a scientific publication in the Journal of Life Sciences Education (Kramer I.M., Dahmani H-R., Delouche P., Bidabe M., Schneeberger P. 2012. Education Catching Up with Science: Preparing Students for Three-Dimensional Literacy in Cell Biology. CBE-Life Sci Educ. 11;437-447). I have also opted for the use of gene names as defined by the HUGO gene nomenclature committee. This is conflicting for some proteins, in the sense that certain symbols are totally different from current common protein names, but the important advantage is that the symbols are (more or less) unambiguous, thus allowing instructors and students to explore proteins further in annotated databases. Among other databases, UniProt and PDB should play an essential role in the process of student “maturation” in life sciences education.
All the images (at high resolution) of the book are available in JPEG format or embedded in Powerpoint slides. Follow to links below to get access.
Finally, I wish to emphasize that instructors should not try to be comprehensive, bringing to the fore as many pathways as possible for the sake of completion. What students make of nicely and logically presented lists of pathways is often a different story than what we have in mind. Allow students time for exploring a limited set of events in their own different ways and from different viewpoints, including the above mentioned annotated databases. There is simply too much to grasp in signal transduction, as in all scientific disciplines. Even as an expert in the field one has to cope with what professor Winkler, back in 1978, named “the explosion of ignorance” (Farewell address of professor Klaas C Winkler, retiring from his chair in Medical Microbiology in 1978 at the University of Utrecht, “de explosie van onkunde of de strijd om het verstaan”, Utrecht University Library, BAB 6682).
for more information about the book go to the elsevier store
you can buy individual chapters at Science Direct , search for "Signal Transduction" and select 3rd edition
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|Last Updated July 14, 2010 3:45 PM | admin news|